Flow carbonylation of sterically hindered ortho-substituted iodoarenes

• Carl J. Mallia,
• Gary C. Walter and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2016, 12, 1503–1511, doi:10.3762/bjoc.12.147

• via a reverse “tube-in-tube” flow reactor at elevated pressures to give yields of carboxylated products that are much higher than those obtained under normal batch conditions. Keywords: carbon monoxide; carbonylation of ortho-substituted substrates; flow chemistry; gases in flow; “tube-in-tube

• for the carbonylation of ortho-substituted substrates which are much more challenging as highlighted by the limited literature precedence [15][16][17]. However, these products are of considerable industrial importance, especially the amide and ester derivatives, which are commonly found in

• continuous flow hydroxy-carbonylation method. Flow carbonylation of 2-iodonaphtalene. Scale up synthesis of 2-chloro-4-fluorobenzoic acid (20). Optimisation for the carbonylation of ortho-substituted substrates in flow. Supporting Information Supporting Information File 427: Experimental part. Supporting